Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

Lorraine A. O’ Reilly, Lin Tai, Lily Lee, Elizabeth A. Kruse, Stephanie Grabow, W. Douglas Fairlie, Nicole M. Haynes, David M. Tarlinton, Jian-Guo Zhang, Gabrielle T. Belz, Mark J. Smyth, Philippe Bouillet, Lorraine Robb and Andreas Strasser ()
Additional contact information
Lorraine A. O’ Reilly: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Lin Tai: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Lily Lee: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Elizabeth A. Kruse: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Stephanie Grabow: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
W. Douglas Fairlie: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Nicole M. Haynes: Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
David M. Tarlinton: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Jian-Guo Zhang: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Gabrielle T. Belz: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Mark J. Smyth: Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Philippe Bouillet: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Lorraine Robb: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Andreas Strasser: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia

Nature, 2009, vol. 461, issue 7264, 659-663

Abstract: FasL's non-apoptotic functions The transmembrane protein known as FasL (Fas ligand) is a member of the tumour necrosis factor family with an important role in immune regulation. The binding of FasL with its receptor induces apoptosis, but it has not been clear how important cell death is in FasL's cellular functions. Experiments using gene-targeted mice that either lack secreted FasL but express normal levels of membrane-bound FasL or, that lack membrane-bound FasL but can still produce secreted FasL, show that soluble FasL promotes autoimmunity and tumorigenesis through mechanisms that do not involve apoptosis.

Date: 2009
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DOI: 10.1038/nature08402

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