TFIIA and the transactivator Rap1 cooperate to commit TFIID for transcription initiation

Gabor Papai, Manish K. Tripathi, Christine Ruhlmann, Justin H. Layer, P. Anthony Weil () and Patrick Schultz ()
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Gabor Papai: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, France
Manish K. Tripathi: Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Christine Ruhlmann: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, France
Justin H. Layer: Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
P. Anthony Weil: Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Patrick Schultz: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, France

Nature, 2010, vol. 465, issue 7300, 956-960

Abstract: Early steps in transcription initiation The early steps of activator-dependent transcription in yeast are examined by determining the cryo-EM structures of the transcription activator Rap1 complexed to general transcription factors TFIID and TFIIA and yeast enhancer–promoter DNA. A model is proposed whereby interactions between Rap1 and TFIIA convey activating signals to TFIID, and a Rap1-dependent DNA loop is visualized between the enhancer and the promoter.

Date: 2010
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DOI: 10.1038/nature09080

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