Differential microRNA regulation of HLA-C expression and its association with HIV control

Smita Kulkarni, Ram Savan, Ying Qi, Xiaojiang Gao, Yuko Yuki, Sara E. Bass, Maureen P. Martin, Peter Hunt, Steven G. Deeks, Amalio Telenti, Florencia Pereyra, David Goldstein, Steven Wolinsky, Bruce Walker, Howard A. Young and Mary Carrington ()
Additional contact information
Smita Kulkarni: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
Ram Savan: Cancer and Inflammation Program, Laboratory of Experimental Immunology, NCI-Frederick
Ying Qi: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
Xiaojiang Gao: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
Yuko Yuki: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
Sara E. Bass: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
Maureen P. Martin: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
Peter Hunt: University of California
Steven G. Deeks: University of California
Amalio Telenti: Institute of Microbiology, University of Lausanne
Florencia Pereyra: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University
David Goldstein: Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University
Steven Wolinsky: The Feinberg School of Medicine, Northwestern University
Bruce Walker: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University
Howard A. Young: Cancer and Inflammation Program, Laboratory of Experimental Immunology, NCI-Frederick
Mary Carrington: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick

Nature, 2011, vol. 472, issue 7344, 495-498

Abstract: An HLA class I gene regulated by microRNA Variation in cell-surface levels and expression of the major histocompatibility complex component HLA-C have been implicated in the control of HIV viral load and progression to AIDS. The microRNA miR-148a is now shown to regulate the expression of HLA-C expression and its effects on HIV. The discovery of a role for a microRNA in this process raises the possibility of new approaches to immunotherapy.

Date: 2011
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature09914 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:472:y:2011:i:7344:d:10.1038_nature09914

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09914

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().