Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

Adelaine K. W. Leung, Kiyoshi Nagai () and Jade Li ()
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Adelaine K. W. Leung: MRC Laboratory of Molecular Biology, Hills Road
Kiyoshi Nagai: MRC Laboratory of Molecular Biology, Hills Road
Jade Li: MRC Laboratory of Molecular Biology, Hills Road

Nature, 2011, vol. 473, issue 7348, 536-539

Abstract: At the core of the spliceosome The complex that excises introns from pre-messenger RNAs, the spliceosome, is composed of ribonucleoprotein subcomplexes, or snRNPs. Most snRNPs contain a core unit of seven Sm proteins, an SMN (survival of motor neurons) chaperone, and an snRNA specific to each snRNP. Leung et al. have solved the structure of the U4 snRNP core. Comparison with a lower-resolution U1 snRNP structure reveals how different snRNAs induce structural changes that permit association of accessory factors that distinguish the various snRNPs.

Date: 2011
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DOI: 10.1038/nature09956

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