Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

Ari J. Firestone, Joshua S. Weinger, Maria Maldonado, Kari Barlan, Lance D. Langston, Michael O’Donnell, Vladimir I. Gelfand, Tarun M. Kapoor () and James K. Chen ()
Additional contact information
Ari J. Firestone: Stanford University School of Medicine
Joshua S. Weinger: Laboratory of Chemistry and Cell Biology, Rockefeller University
Maria Maldonado: Laboratory of Chemistry and Cell Biology, Rockefeller University
Kari Barlan: Northwestern University School of Medicine
Lance D. Langston: Laboratory of Chemistry and Cell Biology, Rockefeller University
Michael O’Donnell: Laboratory of Chemistry and Cell Biology, Rockefeller University
Vladimir I. Gelfand: Northwestern University School of Medicine
Tarun M. Kapoor: Laboratory of Chemistry and Cell Biology, Rockefeller University
James K. Chen: Stanford University School of Medicine

Nature, 2012, vol. 484, issue 7392, 125-129

Abstract: A family of small molecules called ‘ciliobrevins’ are described that can rapidly and reversibly modulate the AAA+ ATPase motor dynein, which transports cargo molecules along microtubule tracks.

Date: 2012
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DOI: 10.1038/nature10936

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