Dissecting the genomic complexity underlying medulloblastoma

David T. W. Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J. Pugh, Volker Hovestadt, Adrian M. Stütz, Tobias Rausch, Hans-Jörg Warnatz, Marina Ryzhova, Sebastian Bender, Dominik Sturm, Sabrina Pleier, Huriye Cin, Elke Pfaff, Laura Sieber, Andrea Wittmann, Marc Remke, Hendrik Witt, Sonja Hutter, Theophilos Tzaridis, Joachim Weischenfeldt, Benjamin Raeder, Meryem Avci, Vyacheslav Amstislavskiy, Marc Zapatka, Ursula D. Weber, Qi Wang, Bärbel Lasitschka, Cynthia C. Bartholomae, Manfred Schmidt, Christof von Kalle, Volker Ast, Chris Lawerenz, Jürgen Eils, Rolf Kabbe, Vladimir Benes, Peter van Sluis, Jan Koster, Richard Volckmann, David Shih, Matthew J. Betts, Robert B. Russell, Simona Coco, Gian Paolo Tonini, Ulrich Schüller, Volkmar Hans, Norbert Graf, Yoo-Jin Kim, Camelia Monoranu, Wolfgang Roggendorf, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Andreas von Deimling, Olaf Witt, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U. Schuhmann, Michael C. Frühwald, Martin Hasselblatt, Nada Jabado, Stefan Rutkowski, André O. von Bueren, Dan Williamson, Steven C. Clifford, Martin G. McCabe, V. Peter Collins, Stephan Wolf, Stefan Wiemann, Hans Lehrach, Benedikt Brors, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Paul A. Northcott, Michael D. Taylor, Matthew Meyerson, Scott L. Pomeroy, Marie-Laure Yaspo, Jan O. Korbel, Andrey Korshunov, Roland Eils (), Stefan M. Pfister () and Peter Lichter ()
Additional contact information
David T. W. Jones: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Natalie Jäger: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Marcel Kool: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Thomas Zichner: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.
Barbara Hutter: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Marc Sultan: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Yoon-Jae Cho: Stanford University, 750 Welch Road, Palo Alto, California 94304, USA.
Trevor J. Pugh: Broad Institute of MIT and Harvard
Volker Hovestadt: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Adrian M. Stütz: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.
Tobias Rausch: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.
Hans-Jörg Warnatz: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Marina Ryzhova: NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16, Moscow 125047, Russia.
Sebastian Bender: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Dominik Sturm: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Sabrina Pleier: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Huriye Cin: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Elke Pfaff: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Laura Sieber: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Andrea Wittmann: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Marc Remke: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Hendrik Witt: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Sonja Hutter: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Theophilos Tzaridis: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Joachim Weischenfeldt: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.
Benjamin Raeder: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.
Meryem Avci: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Vyacheslav Amstislavskiy: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Marc Zapatka: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Ursula D. Weber: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Qi Wang: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Bärbel Lasitschka: Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Cynthia C. Bartholomae: German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.
Manfred Schmidt: German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.
Christof von Kalle: German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.
Volker Ast: Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Chris Lawerenz: Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Jürgen Eils: Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Rolf Kabbe: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Vladimir Benes: Genomics Core Facility, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.
Peter van Sluis: AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.
Jan Koster: AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.
Richard Volckmann: AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.
David Shih: The Arthur and Sonia Labbatt Brain Tumor Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Matthew J. Betts: Cell Networks Cluster of Excellence, University of Heidelberg
Robert B. Russell: Cell Networks Cluster of Excellence, University of Heidelberg
Simona Coco: IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, L.go R. Benzi,10, Genoa 16132, Italy.
Gian Paolo Tonini: IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, L.go R. Benzi,10, Genoa 16132, Italy.
Ulrich Schüller: Center for Neuropathology and Prion Research, University of Munich, Feodor-Lynen-Strasse 23, Munich 81377, Germany.
Volkmar Hans: Institute for Neuropathology, Evangelisches Krankenhaus, Remterweg 2, Bielefeld 33617, Germany.
Norbert Graf: Saarland University Hospital
Yoo-Jin Kim: Institute for Pathology, Saarland University Hospital, Kirrberger Strasse
Camelia Monoranu: Institute of Pathology, Würzburg University Josef-Schneider Strasse 2, Würzburg 97080, Germany.
Wolfgang Roggendorf: Institute of Pathology, Würzburg University Josef-Schneider Strasse 2, Würzburg 97080, Germany.
Andreas Unterberg: Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg 69120, Germany.
Christel Herold-Mende: Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg 69120, Germany.
Till Milde: Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
Andreas E. Kulozik: Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
Andreas von Deimling: University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany.
Olaf Witt: Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
Eberhard Maass: Hematology & Immunology, Klinikum Stuttgart Olgahospital, Bismarckstrasse 8, Stuttgart 70176, Germany.
Jochen Rössler: University Hospital Freiburg, Mathildenstrasse 1, Freiburg 79106, Germany.
Martin Ebinger: Children’s University Hospital, Hoppe-Seyler Strasse 1, Tübingen 72076, Germany.
Martin U. Schuhmann: University Hospital, Hoppe-Seyler Strasse 3
Michael C. Frühwald: Children’s Hospital Augsburg, Stenglinstrasse 2
Martin Hasselblatt: Institute of Neuropathology, University Hospital Münster, Albert-Schweitzer-Campus 1
Nada Jabado: McGill University and the McGill University Health Center Research Institute, Montreal, Quebec H3Z 2Z3, Canada.
Stefan Rutkowski: University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
André O. von Bueren: University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Dan Williamson: Northern Institute for Cancer Research, Newcastle University, Royal Victoria Infirmary, Newcastle-upon-Tyne, NE1 4LP, UK.
Steven C. Clifford: Northern Institute for Cancer Research, Newcastle University, Royal Victoria Infirmary, Newcastle-upon-Tyne, NE1 4LP, UK.
Martin G. McCabe: School of Cancer and Enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PL, UK.
V. Peter Collins: University of Cambridge, Cambridge CB2 0QQ, UK.
Stephan Wolf: Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Stefan Wiemann: Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Hans Lehrach: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Benedikt Brors: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Wolfram Scheurlen: Cnopf’sche Kinderklinik, Nürnberg Children’s Hospital, St-Johannis-Mühlgasse 19
Jörg Felsberg: Heinrich-Heine-University Düsseldorf, Moorenstrasse 5
Guido Reifenberger: Heinrich-Heine-University Düsseldorf, Moorenstrasse 5
Paul A. Northcott: The Arthur and Sonia Labbatt Brain Tumor Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Michael D. Taylor: Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Matthew Meyerson: Broad Institute of MIT and Harvard
Scott L. Pomeroy: Broad Institute of MIT and Harvard
Marie-Laure Yaspo: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Jan O. Korbel: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.
Andrey Korshunov: University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany.
Roland Eils: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Stefan M. Pfister: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Peter Lichter: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

Nature, 2012, vol. 488, issue 7409, 100-105

Abstract: Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of tumour samples the authors show that the clinically challenging Group 3 and 4 tumours can be tetraploid, and reveal the expression of the first medulloblastoma fusion genes identified.

Date: 2012
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DOI: 10.1038/nature11284

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