In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Meritxell Huch, Craig Dorrell, Sylvia F. Boj, Johan H. van Es, Vivian S. W. Li, Marc van de Wetering, Toshiro Sato, Karien Hamer, Nobuo Sasaki, Milton J. Finegold, Annelise Haft, Robert G. Vries, Markus Grompe and Hans Clevers ()
Additional contact information
Meritxell Huch: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
Craig Dorrell: Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University
Sylvia F. Boj: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
Johan H. van Es: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
Vivian S. W. Li: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
Marc van de Wetering: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
Toshiro Sato: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
Karien Hamer: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
Nobuo Sasaki: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
Milton J. Finegold: Texas Children’s Hospital
Annelise Haft: Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University
Robert G. Vries: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
Markus Grompe: Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University
Hans Clevers: Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht

Nature, 2013, vol. 494, issue 7436, 247-250

Abstract: A mouse model of liver damage has identified a population of Lrg5+ liver stem cells that can generate hepatoctyes and bile ducts in vivo.

Date: 2013
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DOI: 10.1038/nature11826

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