Structural basis for the inhibition of bacterial multidrug exporters

Ryosuke Nakashima, Keisuke Sakurai, Seiji Yamasaki, Katsuhiko Hayashi, Chikahiro Nagata, Kazuki Hoshino, Yoshikuni Onodera, Kunihiko Nishino and Akihito Yamaguchi ()
Additional contact information
Ryosuke Nakashima: Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan
Keisuke Sakurai: Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan
Seiji Yamasaki: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan
Katsuhiko Hayashi: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan
Chikahiro Nagata: Daiichi Sankyo Co. Ltd, 16-13, Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan
Kazuki Hoshino: Daiichi Sankyo Co. Ltd, 16-13, Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan
Yoshikuni Onodera: Daiichi Sankyo Co. Ltd, 16-13, Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan
Kunihiko Nishino: Laboratory of Microbiology and Infectious Diseases, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan
Akihito Yamaguchi: Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan

Nature, 2013, vol. 500, issue 7460, 102-106

Abstract: The first inhibitor-bound X-ray crystal structures of the bacterial multidrug efflux transporter AcrB and its homologue MexB are presented, with the inhibitor shown to bind the transporter through a narrow hydrophobic pit, thereby preventing rotation of AcrB and MexB monomers.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature12300 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12300

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12300

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().