Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture

Karl R. Koehler (), Andrew M. Mikosz, Andrei I. Molosh, Dharmeshkumar Patel and Eri Hashino ()
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Karl R. Koehler: Medical Neuroscience Graduate Program, Indiana University School of Medicine
Andrew M. Mikosz: Stark Neurosciences Research Institute, Indiana University School of Medicine
Andrei I. Molosh: Stark Neurosciences Research Institute, Indiana University School of Medicine
Dharmeshkumar Patel: Stark Neurosciences Research Institute, Indiana University School of Medicine
Eri Hashino: Medical Neuroscience Graduate Program, Indiana University School of Medicine

Nature, 2013, vol. 500, issue 7461, 217-221

Abstract: A new approach has been developed in order to achieve the stepwise differentiation of inner ear sensory epithelia from mouse embryonic stem cells in a three-dimensional culture: this process, which mimics normal development and produces cells that have functional characteristics of mechanosensitive hair cells, is hoped to provide further insights into inner ear development and disorder.

Date: 2013
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DOI: 10.1038/nature12298

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