Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

Masashi Shingai, Yoshiaki Nishimura, Florian Klein, Hugo Mouquet, Olivia K. Donau, Ronald Plishka, Alicia Buckler-White, Michael Seaman, Michael Piatak, Jeffrey D. Lifson, Dimiter Dimitrov, Michel C. Nussenzweig () and Malcolm A. Martin ()
Additional contact information
Masashi Shingai: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Yoshiaki Nishimura: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Florian Klein: Laboratory of Molecular Immunology, The Rockefeller University
Hugo Mouquet: Laboratory of Humoral Response to Pathogens, Institut Pasteur, 75015 Paris, France
Olivia K. Donau: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Ronald Plishka: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Alicia Buckler-White: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Michael Seaman: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle
Michael Piatak: AIDS and Cancer Virus Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
Jeffrey D. Lifson: AIDS and Cancer Virus Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
Dimiter Dimitrov: Center for Cancer Research, National Cancer Institute, National Institutes of Health
Michel C. Nussenzweig: Laboratory of Molecular Immunology, The Rockefeller University
Malcolm A. Martin: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Nature, 2013, vol. 503, issue 7475, 277-280

Abstract: A new generation of broad and potent anti-HIV-1 monoclonal antibodies has recently been isolated; co-administration of two such antibodies is shown here to result in rapid and potent suppression of plasma viraemia in five chronically SHIV-infected macaques that lasts for several weeks.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (7)

Downloads: (external link)
https://www.nature.com/articles/nature12746 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:503:y:2013:i:7475:d:10.1038_nature12746

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12746

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().