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RETRACTED ARTICLE: Bidirectional developmental potential in reprogrammed cells with acquired pluripotency

Haruko Obokata (), Yoshiki Sasai (), Hitoshi Niwa, Mitsutaka Kadota, Munazah Andrabi, Nozomu Takata, Mikiko Tokoro, Yukari Terashita, Shigenobu Yonemura, Charles A. Vacanti and Teruhiko Wakayama ()
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Haruko Obokata: Laboratory for Cellular Reprogramming, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Yoshiki Sasai: Laboratory for Organogenesis and Neurogenesis, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Hitoshi Niwa: Laboratory for Pluripotent Stem Cell Studies, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Mitsutaka Kadota: Genome Resource and Analysis Unit, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Munazah Andrabi: Genome Resource and Analysis Unit, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Nozomu Takata: Laboratory for Organogenesis and Neurogenesis, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Mikiko Tokoro: Laboratory for Genomic Reprogramming, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Yukari Terashita: Laboratory for Cellular Reprogramming, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Shigenobu Yonemura: Electron Microscopy Laboratory, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Charles A. Vacanti: Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women’s Hospital, Harvard Medical School
Teruhiko Wakayama: Laboratory for Genomic Reprogramming, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan

Nature, 2014, vol. 505, issue 7485, 676-680

Abstract: One of two papers describing a reprogramming phenomenon called stimulus-triggered acquisition of pluripotency (STAP) — in STAP, lineage-committed adult somatic cells are reprogrammed to pluripotency by transient exposure to low-pH treatment, and extensive analysis of the molecular features and developmental potential of STAP cells indicates that they represent a unique state of pluripotency.

Date: 2014
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DOI: 10.1038/nature12969

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