The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

Magdalena Paolino, Axel Choidas, Stephanie Wallner, Blanka Pranjic, Iris Uribesalgo, Stefanie Loeser, Amanda M. Jamieson, Wallace Y. Langdon, Fumiyo Ikeda, Juan Pablo Fededa, Shane J. Cronin, Roberto Nitsch, Carsten Schultz-Fademrecht, Jan Eickhoff, Sascha Menninger, Anke Unger, Robert Torka, Thomas Gruber, Reinhard Hinterleitner, Gottfried Baier, Dominik Wolf, Axel Ullrich, Bert M. Klebl and Josef M. Penninger ()
Additional contact information
Magdalena Paolino: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Axel Choidas: Lead Discovery Center GmbH, D-44227 Dortmund, Germany
Stephanie Wallner: Medical University Innsbruck, 6020 Innsbruck, Austria
Blanka Pranjic: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Iris Uribesalgo: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Stefanie Loeser: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Amanda M. Jamieson: Brown University
Wallace Y. Langdon: School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Perth, Australia
Fumiyo Ikeda: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Juan Pablo Fededa: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Shane J. Cronin: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Roberto Nitsch: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Carsten Schultz-Fademrecht: Lead Discovery Center GmbH, D-44227 Dortmund, Germany
Jan Eickhoff: Lead Discovery Center GmbH, D-44227 Dortmund, Germany
Sascha Menninger: Lead Discovery Center GmbH, D-44227 Dortmund, Germany
Anke Unger: Lead Discovery Center GmbH, D-44227 Dortmund, Germany
Robert Torka: Max-Planck, Institute for Biochemistry, D-82152 Martinsried, Germany
Thomas Gruber: Medical University Innsbruck, 6020 Innsbruck, Austria
Reinhard Hinterleitner: Medical University Innsbruck, 6020 Innsbruck, Austria
Gottfried Baier: Medical University Innsbruck, 6020 Innsbruck, Austria
Dominik Wolf: Medical University Innsbruck, 6020 Innsbruck, Austria
Axel Ullrich: Max-Planck, Institute for Biochemistry, D-82152 Martinsried, Germany
Bert M. Klebl: Lead Discovery Center GmbH, D-44227 Dortmund, Germany
Josef M. Penninger: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria

Nature, 2014, vol. 507, issue 7493, 508-512

Abstract: The E3 ligase Cbl-b acts on TAM tyrosine kinase receptors and has a critical role in the regulation of natural killer (NK) cell rejection of metastatic tumours; a small molecule TAM kinase inhibitor is shown to enhance the anti-metastatic NK cell activity.

Date: 2014
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DOI: 10.1038/nature12998

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