Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

Mitsutoshi Yamada, Bjarki Johannesson, Ido Sagi, Lisa Cole Burnett, Daniel H. Kort, Robert W. Prosser, Daniel Paull, Michael W. Nestor, Matthew Freeby, Ellen Greenberg, Robin S. Goland, Rudolph L. Leibel, Susan L. Solomon, Nissim Benvenisty, Mark V. Sauer and Dieter Egli ()
Additional contact information
Mitsutoshi Yamada: The New York Stem Cell Foundation Research Institute
Bjarki Johannesson: The New York Stem Cell Foundation Research Institute
Ido Sagi: Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Lisa Cole Burnett: Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University
Daniel H. Kort: Center for Women’s Reproductive Care, College of Physicians and Surgeons, Columbia University
Robert W. Prosser: Center for Women’s Reproductive Care, College of Physicians and Surgeons, Columbia University
Daniel Paull: The New York Stem Cell Foundation Research Institute
Michael W. Nestor: The New York Stem Cell Foundation Research Institute
Matthew Freeby: Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University
Ellen Greenberg: Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University
Robin S. Goland: Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University
Rudolph L. Leibel: Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University
Susan L. Solomon: The New York Stem Cell Foundation Research Institute
Nissim Benvenisty: Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Mark V. Sauer: Center for Women’s Reproductive Care, College of Physicians and Surgeons, Columbia University
Dieter Egli: The New York Stem Cell Foundation Research Institute

Nature, 2014, vol. 510, issue 7506, 533-536

Abstract: Here human embryonic stem cell lines are derived by somatic cell nuclear transfer from cells of a newborn and from skin cells of an adult, a female with type 1 diabetes; the stem cells produced are pluripotent and can be differentiated into insulin-producing beta cells.

Date: 2014
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DOI: 10.1038/nature13287

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