Another action of a thalidomide derivative

Takumi Ito and Hiroshi Handa ()
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Takumi Ito: Tokyo Medical University, Shinjuku-ku, Tokyo, 160-8402, Japan.
Hiroshi Handa: Tokyo Medical University, Shinjuku-ku, Tokyo, 160-8402, Japan.

Nature, 2015, vol. 523, issue 7559, 167-168

Abstract: Lenalidomide effectively treats a blood disorder caused by the 5q chromosomal deletion. A study shows that the drug binds to its target, CRBN, to promote the breakdown of an enzyme encoded by a gene in the 5q region. See Article p.183

Date: 2015
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DOI: 10.1038/nature14628

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