Copper-catalysed enantioselective stereodivergent synthesis of amino alcohols

Shi-Liang Shi, Zackary L. Wong and Stephen L. Buchwald ()
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Shi-Liang Shi: Massachusetts Institute of Technology
Zackary L. Wong: Massachusetts Institute of Technology
Stephen L. Buchwald: Massachusetts Institute of Technology

Nature, 2016, vol. 532, issue 7599, 353-356

Abstract: Here, a method is described by which to generate all possible stereoisomers of certain amino alcohols—a protocol that should see use in drug discovery and development, where it is important to determine the differing effects of stereoisomeric drug candidates.

Date: 2016
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DOI: 10.1038/nature17191

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