Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

Lena M. Kranz, Mustafa Diken, Heinrich Haas, Sebastian Kreiter, Carmen Loquai, Kerstin C. Reuter, Martin Meng, Daniel Fritz, Fulvia Vascotto, Hossam Hefesha, Christian Grunwitz, Mathias Vormehr, Yves Hüsemann, Abderraouf Selmi, Andreas N. Kuhn, Janina Buck, Evelyna Derhovanessian, Richard Rae, Sebastian Attig, Jan Diekmann, Robert A. Jabulowsky, Sandra Heesch, Jessica Hassel, Peter Langguth, Stephan Grabbe, Christoph Huber, Özlem Türeci and Ugur Sahin ()
Additional contact information
Lena M. Kranz: TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
Mustafa Diken: TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
Heinrich Haas: Biopharmaceutical New Technologies (BioNTech) Corporation
Sebastian Kreiter: TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
Carmen Loquai: University Medical Center of the Johannes Gutenberg University
Kerstin C. Reuter: Biopharmaceutical New Technologies (BioNTech) Corporation
Martin Meng: Biopharmaceutical New Technologies (BioNTech) Corporation
Daniel Fritz: Biopharmaceutical New Technologies (BioNTech) Corporation
Fulvia Vascotto: TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
Hossam Hefesha: Biopharmaceutical New Technologies (BioNTech) Corporation
Christian Grunwitz: Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University
Mathias Vormehr: Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University
Yves Hüsemann: Biopharmaceutical New Technologies (BioNTech) Corporation
Abderraouf Selmi: TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
Andreas N. Kuhn: Biopharmaceutical New Technologies (BioNTech) Corporation
Janina Buck: Biopharmaceutical New Technologies (BioNTech) Corporation
Evelyna Derhovanessian: Biopharmaceutical New Technologies (BioNTech) Corporation
Richard Rae: TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
Sebastian Attig: TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
Jan Diekmann: Biopharmaceutical New Technologies (BioNTech) Corporation
Robert A. Jabulowsky: Biopharmaceutical New Technologies (BioNTech) Corporation
Sandra Heesch: Biopharmaceutical New Technologies (BioNTech) Corporation
Jessica Hassel: Heidelberg University Hospital
Peter Langguth: Institute of Pharmacy and Biochemistry, Johannes Gutenberg University
Stephan Grabbe: University Medical Center of the Johannes Gutenberg University
Christoph Huber: TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
Özlem Türeci: Cluster for Individualized Immune Intervention
Ugur Sahin: TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH

Nature, 2016, vol. 534, issue 7607, 396-401

Abstract: The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immunity in mouse tumour models; initial results in advanced melanoma patients indicate potential efficacy in humans.

Date: 2016
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DOI: 10.1038/nature18300

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