A cholinergic basal forebrain feeding circuit modulates appetite suppression

Alexander M. Herman, Joshua Ortiz-Guzman, Mikhail Kochukov, Isabella Herman, Kathleen B. Quast, Jay M. Patel, Burak Tepe, Jeffrey C. Carlson, Kevin Ung, Jennifer Selever, Qingchun Tong and Benjamin R. Arenkiel ()
Additional contact information
Alexander M. Herman: Program in Developmental Biology, Baylor College of Medicine
Joshua Ortiz-Guzman: Program in Developmental Biology, Baylor College of Medicine
Mikhail Kochukov: Baylor College of Medicine
Isabella Herman: Program in Developmental Biology, Baylor College of Medicine
Kathleen B. Quast: Baylor College of Medicine
Jay M. Patel: Medical Scientist Training Program, Baylor College of Medicine
Burak Tepe: Program in Developmental Biology, Baylor College of Medicine
Jeffrey C. Carlson: Program in Developmental Biology, Baylor College of Medicine
Kevin Ung: Program in Developmental Biology, Baylor College of Medicine
Jennifer Selever: Baylor College of Medicine
Qingchun Tong: Institute of Molecular Medicine, University of Texas Health Science Center
Benjamin R. Arenkiel: Program in Developmental Biology, Baylor College of Medicine

Nature, 2016, vol. 538, issue 7624, 253-256

Abstract: A mouse study reveals that acetylcholine signalling networks have a role in the regulation of body weight homeostasis, with increased activity of cholinergic neurons decreasing food consumption through downstream hypothalamic targets.

Date: 2016
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DOI: 10.1038/nature19789

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