Mechanism of early dissemination and metastasis in Her2+ mammary cancer

Kathryn L. Harper, Maria Soledad Sosa (), David Entenberg, Hedayatollah Hosseini, Julie F. Cheung, Rita Nobre, Alvaro Avivar-Valderas, Chandandaneep Nagi, Nomeda Girnius, Roger J. Davis, Eduardo F. Farias, John Condeelis, Christoph A. Klein and Julio A. Aguirre-Ghiso ()
Additional contact information
Kathryn L. Harper: Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place
Maria Soledad Sosa: Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place
David Entenberg: Integrated Imaging Program, Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine
Hedayatollah Hosseini: Experimental Medicine and Therapy Research, University of Regensburg
Julie F. Cheung: Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place
Rita Nobre: Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place
Alvaro Avivar-Valderas: Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place
Chandandaneep Nagi: Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place
Nomeda Girnius: Howard Hughes Medical Institute, University of Massachusetts Medical School
Roger J. Davis: Howard Hughes Medical Institute, University of Massachusetts Medical School
Eduardo F. Farias: Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place
John Condeelis: Integrated Imaging Program, Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine
Christoph A. Klein: Experimental Medicine and Therapy Research, University of Regensburg
Julio A. Aguirre-Ghiso: Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place

Nature, 2016, vol. 540, issue 7634, 588-592

Abstract: Two related papers show that cells disseminated from malignant lesions at early time points during tumorigenesis can contribute to metastases at distant organs and provide insights into the molecular basis of dissemination.

Date: 2016
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DOI: 10.1038/nature20609

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