Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Prasenjit Dey, Joelle Baddour, Florian Muller, Chia Chin Wu, Huamin Wang, Wen-Ting Liao, Zangdao Lan, Alina Chen, Tony Gutschner, Yaan Kang, Jason Fleming, Nikunj Satani, Di Zhao, Abhinav Achreja, Lifeng Yang, Jiyoon Lee, Edward Chang, Giannicola Genovese, Andrea Viale, Haoqiang Ying, Giulio Draetta, Anirban Maitra, Y. Alan Wang (), Deepak Nagrath () and Ronald A. DePinho ()
Additional contact information
Prasenjit Dey: The University of Texas MD Anderson Cancer Center
Joelle Baddour: Rice University
Florian Muller: The University of Texas MD Anderson Cancer Center
Chia Chin Wu: The University of Texas MD Anderson Cancer Center
Huamin Wang: The University of Texas MD Anderson Cancer Center
Wen-Ting Liao: The University of Texas MD Anderson Cancer Center
Zangdao Lan: The University of Texas MD Anderson Cancer Center
Alina Chen: The University of Texas MD Anderson Cancer Center
Tony Gutschner: The University of Texas MD Anderson Cancer Center
Yaan Kang: The University of Texas MD Anderson Cancer Center
Jason Fleming: The University of Texas MD Anderson Cancer Center
Nikunj Satani: The University of Texas MD Anderson Cancer Center
Di Zhao: The University of Texas MD Anderson Cancer Center
Abhinav Achreja: Rice University
Lifeng Yang: Rice University
Jiyoon Lee: Rice University
Edward Chang: The University of Texas MD Anderson Cancer Center
Giannicola Genovese: The University of Texas MD Anderson Cancer Center
Andrea Viale: The University of Texas MD Anderson Cancer Center
Haoqiang Ying: The University of Texas MD Anderson Cancer Center
Giulio Draetta: The University of Texas MD Anderson Cancer Center
Anirban Maitra: The University of Texas MD Anderson Cancer Center
Y. Alan Wang: The University of Texas MD Anderson Cancer Center
Deepak Nagrath: Rice University
Ronald A. DePinho: The University of Texas MD Anderson Cancer Center

Nature, 2017, vol. 542, issue 7639, 119-123

Abstract: Depletion of malic enzyme 3 in pancreatic cancer cells that have a deletion of the gene for malic enzyme 2 selectively kills the cells, suggesting that the enzyme might represent a therapeutic target for this subset of cancers.

Date: 2017
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DOI: 10.1038/nature21052

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