Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

Alejandra Mendoza, Victoria Fang, Cynthia Chen, Madhavika Serasinghe, Akanksha Verma, James Muller, V. Sai Chaluvadi, Michael L. Dustin, Timothy Hla, Olivier Elemento, Jerry E. Chipuk and Susan R. Schwab ()
Additional contact information
Alejandra Mendoza: Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Victoria Fang: Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Cynthia Chen: Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Madhavika Serasinghe: Icahn School of Medicine at Mount Sinai
Akanksha Verma: Institute for Computational Biomedicine, Weill Cornell Medical College
James Muller: Skirball Institute of Biomolecular Medicine, New York University School of Medicine
V. Sai Chaluvadi: Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Michael L. Dustin: Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Timothy Hla: Vascular Biology Program, Boston Children's Hospital, Harvard Medical School
Olivier Elemento: Institute for Computational Biomedicine, Weill Cornell Medical College
Jerry E. Chipuk: Icahn School of Medicine at Mount Sinai
Susan R. Schwab: Skirball Institute of Biomolecular Medicine, New York University School of Medicine

Nature, 2017, vol. 546, issue 7656, 158-161

Abstract: The chemoattractant S1P is identified as an extrinsic factor that supports naive T cell survival, and acts via a signalling mechanism to maintain mitochondrial content and function.

Date: 2017
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DOI: 10.1038/nature22352

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