Applying systems-level spectral imaging and analysis to reveal the organelle interactome

Alex M. Valm, Sarah Cohen, Wesley R. Legant, Justin Melunis, Uri Hershberg, Eric Wait, Andrew R. Cohen, Michael W. Davidson, Eric Betzig and Jennifer Lippincott-Schwartz ()
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Alex M. Valm: Eunice Kennedy Shriver National Institute for Child Health and Human Development, NIH
Sarah Cohen: Eunice Kennedy Shriver National Institute for Child Health and Human Development, NIH
Wesley R. Legant: Janelia Research Campus, Howard Hughes Medical Institute
Justin Melunis: School of Biomedical Engineering, Science and Health Systems, Drexel University
Uri Hershberg: School of Biomedical Engineering, Science and Health Systems, Drexel University
Eric Wait: College of Engineering, Drexel University
Andrew R. Cohen: College of Engineering, Drexel University
Michael W. Davidson: The Florida State University
Eric Betzig: Janelia Research Campus, Howard Hughes Medical Institute
Jennifer Lippincott-Schwartz: Eunice Kennedy Shriver National Institute for Child Health and Human Development, NIH

Nature, 2017, vol. 546, issue 7656, 162-167

Abstract: Using confocal and lattice light sheet microscopy, the authors perform systems-level analysis of the organelle interactome in live cells, allowing them to visualize the frequency and locality of up to five-way interactions between different organelles.

Date: 2017
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DOI: 10.1038/nature22369

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