The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition

Gabriele Varano, Simon Raffel, Martina Sormani, Federica Zanardi, Silvia Lonardi, Christin Zasada, Laura Perucho, Valentina Petrocelli, Andrea Haake, Albert K. Lee, Mattia Bugatti, Ulrike Paul, Eelco Van Anken, Laura Pasqualucci, Raul Rabadan, Reiner Siebert, Stefan Kempa, Maurilio Ponzoni, Fabio Facchetti, Klaus Rajewsky and Stefano Casola ()
Additional contact information
Gabriele Varano: IFOM, the FIRC Institute of Molecular Oncology
Simon Raffel: Heidelberg Institute for Stem Cell Technology and Experimental Medicine
Martina Sormani: IFOM, the FIRC Institute of Molecular Oncology
Federica Zanardi: IFOM, the FIRC Institute of Molecular Oncology
Silvia Lonardi: Section of Pathology, University of Brescia
Christin Zasada: Max-Delbrück-Center of Molecular Medicine in the Helmholtz Association
Laura Perucho: IFOM, the FIRC Institute of Molecular Oncology
Valentina Petrocelli: IFOM, the FIRC Institute of Molecular Oncology
Andrea Haake: Institute of Human Genetics, Christian-Albrechts-University Kiel
Albert K. Lee: Columbia University
Mattia Bugatti: Section of Pathology, University of Brescia
Ulrike Paul: Institute of Human Genetics, Christian-Albrechts-University Kiel
Eelco Van Anken: San Raffaele Scientific Institute
Laura Pasqualucci: Herbert Irving Comprehensive Cancer Center, Columbia University
Raul Rabadan: Columbia University
Reiner Siebert: Institute of Human Genetics, Christian-Albrechts-University Kiel
Stefan Kempa: Max-Delbrück-Center of Molecular Medicine in the Helmholtz Association
Maurilio Ponzoni: Ateneo Vita Salute and San Raffaele Scientific Institute, Pathology and Lymphoid Malignancies Units
Fabio Facchetti: Section of Pathology, University of Brescia
Klaus Rajewsky: Max-Delbrück-Center of Molecular Medicine in the Helmholtz Association
Stefano Casola: IFOM, the FIRC Institute of Molecular Oncology

Nature, 2017, vol. 546, issue 7657, 302-306

Abstract: Combined studies in MYC-driven mouse lymphomas and human Burkitt lymphoma unravel an essential role for the B-cell antigen receptor in the control of tumour B-cell fitness both in vitro and in vivo, with possible biological and clinical implications.

Date: 2017
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DOI: 10.1038/nature22353

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