Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

Markus Brockmann, Vincent A. Blomen, Joppe Nieuwenhuis, Elmer Stickel, Matthijs Raaben, Onno B. Bleijerveld, A. F. Maarten Altelaar, Lucas T. Jae () and Thijn R. Brummelkamp ()
Additional contact information
Markus Brockmann: Netherlands Cancer Institute
Vincent A. Blomen: Netherlands Cancer Institute
Joppe Nieuwenhuis: Netherlands Cancer Institute
Elmer Stickel: Netherlands Cancer Institute
Matthijs Raaben: Netherlands Cancer Institute
Onno B. Bleijerveld: Netherlands Cancer Institute
A. F. Maarten Altelaar: Netherlands Cancer Institute
Lucas T. Jae: Netherlands Cancer Institute
Thijn R. Brummelkamp: Netherlands Cancer Institute

Nature, 2017, vol. 546, issue 7657, 307-311

Abstract: Random mutagenesis in haploid human cells coupled to quantitative protein measurements with different antibodies is used as a readout for individual cellular phenotypes.

Date: 2017
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DOI: 10.1038/nature22376

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