Microglia-dependent synapse loss in type I interferon-mediated lupus

Allison R. Bialas, Jessy Presumey, Abhishek Das, Cees E. van der Poel, Peter H. Lapchak, Luka Mesin, Gabriel Victora, George C. Tsokos, Christian Mawrin, Ronald Herbst and Michael C. Carroll ()
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Allison R. Bialas: Program in Cellular and Molecular Medicine, Harvard Medical School
Jessy Presumey: Program in Cellular and Molecular Medicine, Harvard Medical School
Abhishek Das: Program in Cellular and Molecular Medicine, Harvard Medical School
Cees E. van der Poel: Program in Cellular and Molecular Medicine, Harvard Medical School
Peter H. Lapchak: Beth Israel Deaconess Medical Center, Harvard Medical School
Luka Mesin: Laboratory for Lymphocyte Dynamics, The Rockefeller University
Gabriel Victora: Laboratory for Lymphocyte Dynamics, The Rockefeller University
George C. Tsokos: Beth Israel Deaconess Medical Center, Harvard Medical School
Christian Mawrin: University of Magdeburg
Ronald Herbst: MedImmune LLC
Michael C. Carroll: Program in Cellular and Molecular Medicine, Harvard Medical School

Nature, 2017, vol. 546, issue 7659, 539-543

Abstract: Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.

Date: 2017
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DOI: 10.1038/nature22821

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