Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3

Marscha Hirschi, Mark A. Herzik, Jinhong Wie, Yang Suo, William F. Borschel, Dejian Ren, Gabriel C. Lander () and Seok-Yong Lee ()
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Marscha Hirschi: Duke University School of Medicine
Mark A. Herzik: The Scripps Research Institute
Jinhong Wie: University of Pennsylvania
Yang Suo: Duke University School of Medicine
William F. Borschel: Duke University School of Medicine
Dejian Ren: University of Pennsylvania
Gabriel C. Lander: The Scripps Research Institute
Seok-Yong Lee: Duke University School of Medicine

Nature, 2017, vol. 550, issue 7676, 411-414

Abstract: A cryo-electron microscopy structure shows that the mucolipin domain of the lysosomal calcium channel TRPML3 binds phosphatidylinositol-3,5-bisphosphate and gates the channel.

Date: 2017
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DOI: 10.1038/nature24055

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