Senescence-associated reprogramming promotes cancer stemness

Maja Milanovic, Dorothy N. Y. Fan, Dimitri Belenki, J. Henry M. Däbritz, Zhen Zhao, Yong Yu, Jan R. Dörr, Lora Dimitrova, Dido Lenze, Ines A. Monteiro Barbosa, Marco A. Mendoza-Parra, Tamara Kanashova, Marlen Metzner, Katharina Pardon, Maurice Reimann, Andreas Trumpp, Bernd Dörken, Johannes Zuber, Hinrich Gronemeyer, Michael Hummel, Gunnar Dittmar, Soyoung Lee and Clemens A. Schmitt ()
Additional contact information
Maja Milanovic: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
Dorothy N. Y. Fan: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
Dimitri Belenki: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
J. Henry M. Däbritz: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
Zhen Zhao: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center
Yong Yu: Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
Jan R. Dörr: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
Lora Dimitrova: Charité – Universitätsmedizin Berlin
Dido Lenze: Charité – Universitätsmedizin Berlin
Ines A. Monteiro Barbosa: Institute of Molecular Pathology (IMP), Vienna Biocenter
Marco A. Mendoza-Parra: Equipe Labellisée Ligue Contre le Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, UMR7104, Institut National de la Santé et de la Recherche Médicale, U964, Université de Strasbourg
Tamara Kanashova: Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
Marlen Metzner: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
Katharina Pardon: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
Maurice Reimann: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
Andreas Trumpp: Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium)
Bernd Dörken: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
Johannes Zuber: Institute of Molecular Pathology (IMP), Vienna Biocenter
Hinrich Gronemeyer: Equipe Labellisée Ligue Contre le Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, UMR7104, Institut National de la Santé et de la Recherche Médicale, U964, Université de Strasbourg
Michael Hummel: Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium)
Gunnar Dittmar: Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
Soyoung Lee: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
Clemens A. Schmitt: Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus

Nature, 2018, vol. 553, issue 7686, 96-100

Abstract: Cellular senescence induced by chemotherapy leads to the acquisition of stemness in cancer cells, which results in enhanced tumour-promoting capacity after forced release or spontaneous escape from the senescent cell-cycle arrest.

Date: 2018
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DOI: 10.1038/nature25167

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