STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma

Jing Hu, Francisco J. Sánchez-Rivera, Zhenghan Wang, Gabriela N. Johnson, Yu-jui Ho, Karuna Ganesh, Shigeaki Umeda, Siting Gan, Adriana M. Mujal, Rebecca B. Delconte, Jessica P. Hampton, Huiyong Zhao, Sanjay Kottapalli, Elisa de Stanchina, Christine A. Iacobuzio-Donahue, Dana Pe’er, Scott W. Lowe, Joseph C. Sun and Joan Massagué ()
Additional contact information
Jing Hu: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Francisco J. Sánchez-Rivera: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Zhenghan Wang: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Gabriela N. Johnson: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Yu-jui Ho: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Karuna Ganesh: Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Shigeaki Umeda: Memorial Sloan Kettering Cancer Center
Siting Gan: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Adriana M. Mujal: Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Rebecca B. Delconte: Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Jessica P. Hampton: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Huiyong Zhao: Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center
Sanjay Kottapalli: Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Elisa de Stanchina: Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center
Christine A. Iacobuzio-Donahue: Memorial Sloan Kettering Cancer Center
Dana Pe’er: Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Scott W. Lowe: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Joseph C. Sun: Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Joan Massagué: Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center

Nature, 2023, vol. 616, issue 7958, 806-813

Abstract: Abstract Metastasis frequently develops from disseminated cancer cells that remain dormant after the apparently successful treatment of a primary tumour. These cells fluctuate between an immune-evasive quiescent state and a proliferative state liable to immune-mediated elimination1–6. Little is known about the clearing of reawakened metastatic cells and how this process could be therapeutically activated to eliminate residual disease in patients. Here we use models of indolent lung adenocarcinoma metastasis to identify cancer cell-intrinsic determinants of immune reactivity during exit from dormancy. Genetic screens of tumour-intrinsic immune regulators identified the stimulator of interferon genes (STING) pathway as a suppressor of metastatic outbreak. STING activity increases in metastatic progenitors that re-enter the cell cycle and is dampened by hypermethylation of the STING promoter and enhancer in breakthrough metastases or by chromatin repression in cells re-entering dormancy in response to TGFβ. STING expression in cancer cells derived from spontaneous metastases suppresses their outgrowth. Systemic treatment of mice with STING agonists eliminates dormant metastasis and prevents spontaneous outbreaks in a T cell- and natural killer cell-dependent manner—these effects require cancer cell STING function. Thus, STING provides a checkpoint against the progression of dormant metastasis and a therapeutically actionable strategy for the prevention of disease relapse.

Date: 2023
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DOI: 10.1038/s41586-023-05880-5

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