Natural killer cell therapies

Eric Vivier (), Lucas Rebuffet, Emilie Narni-Mancinelli, Stéphanie Cornen, Rob Y. Igarashi and Valeria R. Fantin
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Eric Vivier: Innate Pharma
Lucas Rebuffet: Aix Marseille Université, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy
Emilie Narni-Mancinelli: Aix Marseille Université, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy
Stéphanie Cornen: Innate Pharma
Rob Y. Igarashi: Sanofi Oncology Research
Valeria R. Fantin: Sanofi Oncology Research

Nature, 2024, vol. 626, issue 8000, 727-736

Abstract: Abstract Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK cells is their ability to recognize a wide range of cells in distress, particularly tumour cells and cells infected with viruses. They combine both direct effector functions against their cellular targets and participate in the generation, shaping and maintenance of a multicellular immune response. As our understanding has deepened, several therapeutic strategies focused on NK cells have been conceived and are currently in various stages of development, from preclinical investigations to clinical trials. Here we explore in detail the complexity of NK cell biology in humans and highlight the role of these cells in cancer immunity. We also analyse the harnessing of NK cell immunity through immune checkpoint inhibitors, NK cell engagers, and infusions of preactivated or genetically modified, autologous or allogeneic NK cell products.

Date: 2024
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DOI: 10.1038/s41586-023-06945-1

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