Critiplot: A Comprehensive Python Package and Web Tool for Visualizing Risk-of-Bias Assessments in Evidence Synthesis

Vihaan Sahu

No 8dtfq_v1, MetaArXiv from Center for Open Science

Abstract: Objective: Risk-of-bias (RoB) assessment is a critical component of evidence synthesis, yet visualization of these assessments remains challenging due to the diversity of assessment tools and a lack of standardized visualization approaches. This study aimed to develop Critiplot, a comprehensive solution comprising a Python package and a web tool that supports visualization of multiple RoB assessment frameworks including the Newcastle-Ottawa Scale (NOS), ROBIS, JBI checklists for case reports and case series, and GRADE – a combination not comprehensively supported by any existing single tool. Critiplot is the first tool to generate publication-ready visualizations for each of these frameworks separately, as well as in a unified manner. Methods: Critiplot was developed using Python 3.11, with Streamlit for the web interface, and as a standalone Python package. The tool supports five major RoB assessment tools: Newcastle-Ottawa Scale (NOS), GRADE, ROBIS, JBI Case Report, and JBI Case Series. The tool was evaluated through a technical assessment of its visualization capabilities and a comparative analysis with existing visualization tools. Test datasets were created to represent typical use cases for each assessment tool, including variations in study numbers, RoB distributions, and data formats. Edge case datasets were also created to test the tool's handling of missing data, invalid scores, and inconsistent formatting. Results: Critiplot successfully generates publication-ready traffic light plots and weighted bar plots for all supported assessment tools. The tool offers multiple visualization themes and supports various output formats (PNG, PDF, SVG, EPS). Critiplot is the first tool to generate publication-ready visualizations for NOS, ROBIS, JBI, and GRADE assessments both individually for each framework and in a unified manner within a single platform. The Python package allows for programmatic integration into analysis pipelines, while the web application provides an accessible interface for users without programming experience. Performance evaluation showed that Critiplot efficiently handled datasets of varying sizes, with processing times ranging from 1.5 seconds for 3 studies to 3.8 seconds for 10 studies. The tool demonstrated robustness in handling edge cases, providing clear error messages in 98% of test cases with invalid inputs. Conclusion: Critiplot addresses a significant gap in evidence synthesis methodologies by providing a unified, reproducible approach to RoB visualization across multiple assessment frameworks. Its unique capability to visualize each framework separately (NOS, ROBIS, JBI, and GRADE) alongside unified visualization makes it a pioneering solution. Its open-source design and intuitive interface (both as a package and web tool) make it a valuable addition to the biomedical informatics toolkit, promoting methodological standardization and enhancing the clarity and reproducibility of RoB assessments.

Date: 2025-10-29
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Persistent link: https://EconPapers.repec.org/RePEc:osf:metaar:8dtfq_v1

DOI: 10.31219/osf.io/8dtfq_v1

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