Time Trend in Persistent Cognitive Decline: Results From the Longitudinal Aging Study Amsterdam

Tessa N van den KommerPhD, Dorly J H DeegPhD, Wiesje M van der FlierPhD and Hannie C ComijsPhD

The Journals of Gerontology: Series B, 2018, vol. 73, issue suppl_1, S57-S64

Abstract: ObjectiveTo study time trends in the incidence of persistent cognitive decline (PCD), and whether an increase or decrease is explained by changes in well-known risk factors of dementia.MethodData from the Longitudinal Aging Study Amsterdam over a period of 20 years were used. Subsamples of 65–88 year-olds were selected at 7 waves, with numbers ranging from 1,800 to 1,165. Within-person change in cognitive functioning was used to determine PCD. In logistic generalized estimating equations (GEE), time (0, 3, 6, 9, 13, and 16 years) was the main predictor of 3-year PCD incidence. Explanatory variables were lagged one wave before incident PCD and included in separate models.ResultsPCD incidence was 2.5% at first, and 3.4% at last follow-up. GEE showed a positive time trend for PCD incidence [Exp(B)time = 1.042; p < .001]. None of the explanatory variables significantly changed the strength of the regression coefficient of linear time. Higher age, lower education, diabetes mellitus, smoking, lower body-mass index, and lower level of physical activity were associated with higher incidence of PCD.ConclusionAn increase in PCD incidence over time was found. Although well-known risk factors were associated with incidence per se, they did not explain the increase in incidence of PCD.

Keywords: Dementia; Incidence; Older adults; Risk factors (search for similar items in EconPapers)
Date: 2018
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The Journals of Gerontology: Series B is currently edited by Psychological Sciences - S. Duke Han, PhD and Social Sciences - Jessica A Kelley, PhD, FGSA

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