Improving our understanding of the biology of aging: findings from the Age-It Research Program

Fabrizio Chiti, Fiorenzo Conti, Daniela Corda, Francesco Giorgino, Andrea Graziani, Giuseppe Passarino, 8rco Sandri and Fabrizio d’Adda di Fagagna

The Journals of Gerontology: Series B, 2025, vol. 80, issue Supplement_2, S122-S135

Abstract: ObjectivesAging mechanisms at both cellular and organisl levels rein poorly understood, as do the factors influencing the variability in aging rates across organs and individuals. Our work aims to identify the key biological pathways that drive aging, determine the most relevant biorkers of biological aging, and uncover actionable mechanisms to improve risk prediction for unsuccessful aging.MethodsTo achieve these objectives, we employ a structured approach that includes (a) investigating the molecular and cellular mechanisms underlying aging, (b) identifying and validating biorkers associated with biological aging, and (c) assessing potential therapeutic targets that could modulate aging-related processes. These efforts are being carried out within the framework of the Age-It initiative, leveraging interdisciplinary methodologies and advanced analytical tools.ResultsOngoing studies within Age-It are generating insights into aging-related pathways and biorkers. Preliminary findings highlight specific molecular signatures associated with biological aging and suggest potential intervention points for mitigating age-related decline.DiscussionUnderstanding the biological underpinnings of aging will enhance our ability to predict and potentially modify aging trajectories. By identifying reliable biorkers and actionable pathways, this research y contribute to the development of targeted interventions to promote healthy aging. The Age-It initiative represents a collaborative effort to translate these findings into practical applications for aging research and health care policy.

Keywords: Cellular senescence; Frailty; Biorkers (search for similar items in EconPapers)
Date: 2025
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