Associations between joint air pollution exposure, mental health, and physical health and dementia incidence in an aging U.S. cohort

Kayan Clarke, Zhengyi Deng, Aisha S Dickerson and Samuele Zilioli

The Journals of Gerontology: Series B, 2026, vol. 81, issue 3, gbaf275.

Abstract: ObjectivesUnderstanding the joint relationship between air pollution and other risk factors on the risk of Alzheimer’s disease and related dementias (ADRD) is important for determining priorities for interventions. This study aimed to estimate the joint effects of air pollution, mental health symptoms, and overall physical health condition on ADRD risk in a U.S. sample of older adults and examine differences by sex.MethodsAnalyses include 9,186 Medicare beneficiaries enrolled in the National Health and Aging Trends Study (2011–2018). We used quantile g-computation Cox proportional hazard models to examine the joint effects of air pollution, anxiety, depression, and overall health on ADRD incidence, stratified by sex.ResultsWe found significant associations between ADRD risk and particulate matter

Keywords: Anxiety; Depression; Joint exposures; Multipollutant risk assessment (search for similar items in EconPapers)
Date: 2026
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