Selective and Genetic Constraints on Pneumococcal Serotype Switching

Nicholas J Croucher, Lisa Kagedan, Claudette M Thompson, Julian Parkhill, Stephen D Bentley, Jonathan A Finkelstein, Marc Lipsitch and William P Hanage

PLOS Genetics, 2015, vol. 11, issue 3, 1-21

Abstract: Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into “serogroups” based on cross-reactivity with certain antibodies. Pneumococci can alter their serotype through recombinations affecting the capsule polysaccharide synthesis (cps) locus. Twenty such “serotype switching” events were fully characterised using a collection of 616 whole genome sequences from systematic surveys of pneumococcal carriage. Eleven of these were within-serogroup switches, representing a highly significant (p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1005095

DOI: 10.1371/journal.pgen.1005095

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