Functional Translational Readthrough: A Systems Biology Perspective

Fabian Schueren and Sven Thoms

PLOS Genetics, 2016, vol. 12, issue 8, 1-12

Abstract: Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1006196

DOI: 10.1371/journal.pgen.1006196

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