Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues

Heather E Wheeler, Kaanan P Shah, Jonathon Brenner, Tzintzuni Garcia, Keston Aquino-Michaels, GTEx Consortium, Nancy J Cox, Dan L Nicolae and Hae Kyung Im

PLOS Genetics, 2016, vol. 12, issue 11, 1-23

Abstract: Understanding the genetic architecture of gene expression traits is key to elucidating the underlying mechanisms of complex traits. Here, for the first time, we perform a systematic survey of the heritability and the distribution of effect sizes across all representative tissues in the human body. We find that local h2 can be relatively well characterized with 59% of expressed genes showing significant h2 (FDR

Date: 2016
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Citations: View citations in EconPapers (4)

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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1006423

DOI: 10.1371/journal.pgen.1006423

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