Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Lesseur, Corina; Ferreiro-Iglesias, Aida; McKay, James D; Bossé, Yohan; Johansson, Mattias; Gaborieau, Valerie; Landi, Maria Teresa; Christiani, David C; Caporaso, Neil C; Bojesen, Stig E; Amos, Christopher I; Shete, Sanjay; Liu, Geoffrey; Rennert, Gadi; Albanes, Demetrios; Aldrich, Melinda C; Tardon, Adonina; Chen, Chu; Triantafillos, Liloglou; Field, John K; Teare, Marion Dawn; Kiemeney, Lambertus A; Diergaarde, Brenda; Ferris, Robert L; Zienolddiny, Shanbeh; Lam, Stephen; Olshan, Andrew F; Weissler, Mark C; Lacko, Martin; Risch, Angela; Bickeböller, Heike; Ness, Andy R; Thomas, Steve; Marchand, Loic Le; Schabath, Matthew B; Wünsch-Filho, Victor; Tajara, Eloiza H; Andrew, Angeline S; Clifford, Gary M; Lazarus, Philip; Grankvist, Kjell; Johansson, Mikael; Arnold, Susanne; Melander, Olle; Brunnström, Hans; Boccia, Stefania; Cadoni, Gabriella; Timens, Wim; Obeidat, Ma’en; Xiao, Xiangjun; Houlston, Richard S; Hung, Rayjean J; Brennan, Paul

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Corina Lesseur, Aida Ferreiro-Iglesias, James D McKay, Yohan Bossé, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C Christiani, Neil C Caporaso, Stig E Bojesen, Christopher I Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrios Albanes, Melinda C Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K Field, Marion Dawn Teare, Lambertus A Kiemeney, Brenda Diergaarde, Robert L Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F Olshan, Mark C Weissler, Martin Lacko, Angela Risch, Heike Bickeböller, Andy R Ness, Steve Thomas, Loic Le Marchand, Matthew B Schabath, Victor Wünsch-Filho, Eloiza H Tajara, Angeline S Andrew, Gary M Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnström, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma’en Obeidat, Xiangjun Xiao, Richard S Houlston, Rayjean J Hung and Paul Brennan

PLOS Genetics, 2021, vol. 17, issue 3, 1-19

Abstract: Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1009254

DOI: 10.1371/journal.pgen.1009254

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