Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition

Mamun Kabir, Masud Alam, Uma Nayak, Tuhinur Arju, Biplob Hossain, Rubaiya Tarannum, Amena Khatun, Jennifer A White, Jennie Z Ma, Rashidul Haque, William A Petri and Carol A Gilchrist

PLOS Pathogens, 2021, vol. 17, issue 6, 1-18

Abstract: We conducted a longitudinal study of cryptosporidiosis from birth to three years of age in an urban slum of Dhaka Bangladesh. Fecal DNA was extracted from monthly surveillance samples and diarrheal stool samples collected from 392 infants from birth to three years. A pan-Cryptosporidium qPCR assay was used to identify sub-clinical and symptomatic cryptosporidiosis. Anthropometric measurements were collected quarterly to assess child nutritional status. 31% (121/392) of children experienced a single and 57% (222/392) multiple infections with Cryptosporidium. Repeat infections had a lower burden of parasites in the stool (Cq slope = -1.85; p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:ppat00:1009445

DOI: 10.1371/journal.ppat.1009445

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