Health Utilities in People with Hepatitis C Virus Infection: A Study Using Real-World Population-Level Data

Yasmin A. Saeed, Nicholas Mitsakakis, Jordan J. Feld, Murray D. Krahn, Jeffrey C. Kwong and William W. L. Wong
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Yasmin A. Saeed: Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
Nicholas Mitsakakis: Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
Jordan J. Feld: Toronto Centre for Liver Disease, University Health Network, Toronto, ON, Canada
Murray D. Krahn: Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
Jeffrey C. Kwong: ICES, Toronto, ON, Canada
William W. L. Wong: Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada

Medical Decision Making, 2025, vol. 45, issue 3, 332-343

Abstract: Background Hepatitis C virus (HCV) infection is associated with reduced quality of life and health utility. It is unclear whether this is primarily due to HCV infection itself or commonly co-occurring patient characteristics such as low income and mental health issues. This study aims to estimate and separate the effects of HCV infection on health utility from the effects of clinical and sociodemographic factors using real-world population-level data. Methods We conducted a cross-sectional retrospective cohort study to estimate health utilities in people with and without HCV infection in Ontario, Canada, from 2000 to 2014 using linked survey data from the Canadian Community Health Survey and health administrative data. Utilities were derived from the Health Utilities Index Mark 3 instrument. We used propensity score matching and multivariable linear regression to examine the impact of HCV infection on utility scores while adjusting for clinical and sociodemographic factors. Results There were 7,102 individuals with hepatitis C status and health utility data available (506 HCV-positive, 6,596 HCV-negative). Factors associated with marginalization were more prevalent in the HCV-positive cohort (e.g., household income

Keywords: hepatitis C; viral hepatitis; health utilities; patient preferences; health-related quality of life; patient reported outcome measures; quality-adjusted life years; cost-effectiveness analysis (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:sae:medema:v:45:y:2025:i:3:p:332-343

DOI: 10.1177/0272989X251319342

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