Analyzing and Optimizing the Throughput of a Pharmaceutical Production Process

Heiner Ackermann (), Sandy Heydrich () and Christian Weiß ()
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Heiner Ackermann: Fraunhofer Institute for Industrial Mathematics ITWM
Sandy Heydrich: Fraunhofer Institute for Industrial Mathematics ITWM
Christian Weiß: Fraunhofer Institute for Industrial Mathematics ITWM

A chapter in Operations Research Proceedings 2019, 2020, pp 591-597 from Springer

Abstract: Abstract We describe a planning and scheduling problem arising from a pharmaceutical application. In a complex production process, individualized drugs are produced in a flow-shop like process with multiple dedicated batching machines at each process stage. Furthermore, due to errors jobs might recirculate to earlier stages and get re-processed. Motivated by the practical application, we investigate techniques for improving the performance of the process. First, we study some simple scheduling heuristics and evaluate their performance using simulations. Second, we show how the scheduling results can also be improved significantly by slightly increasing the number of machines at some crucial points.

Keywords: Flow shop; Batching; Recirculation; Production planning; Process capacity (search for similar items in EconPapers)
Date: 2020
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DOI: 10.1007/978-3-030-48439-2_72

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