Has It Really Been Demonstrated That Most Genomic Research Findings Are False?

Gregory P. Samsa

The American Statistician, 2015, vol. 69, issue 1, 1-4

Abstract: In a widely cited article, Ioannidis argued that most published research findings are false; particularly discovery research involving massive testing, genomics being a typical example. However, his argument ignores adjustment for multiple testing and thus should be taken with a large grain of salt. This is a potential example for statistics courses that concentrate on problem formulation.

Date: 2015
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DOI: 10.1080/00031305.2014.951127

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