A numerical solution of the mechanical bidomain model

Samip Gandhi and Bradley J. Roth

Computer Methods in Biomechanics and Biomedical Engineering, 2016, vol. 19, issue 10, 1099-1106

Abstract: Introduction: The mechanical bidomain model predicts forces on integrin proteins in the membrane. It has been solved analytically for idealized examples, but a numerical algorithm is needed to address realistic problems. Methods: The bidomain equations are approximated using finite differences. An ischemic region is modeled as a circular area having no active tension, surrounded by normal tissue. Results: The membrane force is large in the ischemic border zone, but is small elsewhere. Strain is distributed widely throughout the ischemic region and surrounding tissue. Conclusion: This calculation provides a testable prediction for the mechanism of mechanotransduction and remodeling in cardiac tissue.

Date: 2016
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DOI: 10.1080/10255842.2015.1105964

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