Efficient computational simulation of actin stress fiber remodeling

T. Ristori, C. Obbink-Huizer, C.W.J. Oomens, F.P.T. Baaijens and S. Loerakker

Computer Methods in Biomechanics and Biomedical Engineering, 2016, vol. 19, issue 12, 1347-1358

Abstract: Understanding collagen and stress fiber remodeling is essential for the development of engineered tissues with good functionality. These processes are complex, highly interrelated, and occur over different time scales. As a result, excessive computational costs are required to computationally predict the final organization of these fibers in response to dynamic mechanical conditions. In this study, an analytical approximation of a stress fiber remodeling evolution law was derived. A comparison of the developed technique with the direct numerical integration of the evolution law showed relatively small differences in results, and the proposed method is one to two orders of magnitude faster.

Date: 2016
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DOI: 10.1080/10255842.2016.1140748

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