Radiation-induced changes in load-sharing and structure-function behavior in murine lumbar vertebrae

Tongge Wu, Noah B. Bonnheim, Megan M. Pendleton, Shannon R. Emerzian and Tony M. Keaveny

Computer Methods in Biomechanics and Biomedical Engineering, 2024, vol. 27, issue 10, 1278-1286

Abstract: In this study, we used micro-CT-based finite element analysis to investigate the biomechanical effects of radiation on the microstructure and mechanical function of murine lumbar vertebrae. Specifically, we evaluated vertebral microstructure, whole-bone stiffness, and cortical-trabecular load sharing in the L5 vertebral body of mice exposed to ionizing radiation 11 days post exposure (5 Gy total dose; n = 13) and controls (n = 14). Our findings revealed the irradiated group exhibited reduced trabecular bone volume and microstructure (p

Date: 2024
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DOI: 10.1080/10255842.2023.2239415

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