Biomechanical evaluation of porcine lens capsule with and without nucleus after capsulotomy – Finite element analysis

Yoke-Rung Wong, Geraint P. Williams, Benjamin L. George, Gary Hin-Fai Yam, Marcus Han-Nian Ang, Jodhbir S. Mehta and Shian-Chao Tay

Computer Methods in Biomechanics and Biomedical Engineering, 2025, vol. 28, issue 14, 2204-2211

Abstract: Previous studies have shown that the nucleus could offer structural support to the lens capsule. This study investigated the biomechanical performance of porcine lens with and without nucleus for 4 mm, 4.5 mm, 5 mm, 5.5 mm and 6 mm capsulotomy and its potential impact on the stretch ratio of capsular bag when the anterior capsulotomy edge was stretched. Our simulation results showed higher strain for the capsular bag with nucleus, which is crucial for the porcine lens to tolerate more stretch without failure. This simulation could support future study on the optimization of capsulotomy based on patient specific condition, that is, the geometry of lens.

Date: 2025
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DOI: 10.1080/10255842.2024.2364812

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