Identification and segregation of genes with improved recurrent neural network trained with optimal gene level and mutation level features

Irfan Rashid Pukhta and Ranjeet Kumar Rout

Computer Methods in Biomechanics and Biomedical Engineering, 2025, vol. 28, issue 8, 1111-1126

Abstract: Even though many different approaches have been employed to address the complex mutational heterogeneity of cancer, finding driver genes is still problematic since other genomic factors cannot be fully integrated for combined analyses. This research paper presents a novel gene identification and segregation model with five key processes (a) pre-processing, (b) treatment of class imbalances, (c) feature extraction, (d) feature selection, and (e) gene classification. To increase the data quality, the gathered initial information is first pre-processed utilizing data cleaning and data normalization. This turns the raw data into something that is both useful and effective. In actuality, the sample is skewed against drivers because passenger mutation markers appear in proportionally less instances than drivers do. To address the Class Imbalance Problem, improved K-Means + SMOTE are applied to the preprocessed data. The most crucial characteristics, including those at the gene and mutation levels, are then extracted from the balanced dataset. To lessen the computational load in terms of time, the best features from the retrieved features are selected using Forensic interpretation tailored hunger food search optimization (FIHFSO). The ideal features are used to train the deep learning classifier that conducts the separation procedure. In this research, an Improved Recurrent Neural Network (I-RNN) is used to make a final decision about genes. At 90% of learning percentage, the accuracy of the proposed method achieves 0.98% of 0.83, 0.81, 0.65, 0.80, 0.92 and 0.63% which is compared to the other methods like HGS, FBIO, AOA, AO, GOA and PRO respectively.

Date: 2025
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DOI: 10.1080/10255842.2024.2311322

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