CFD simulation of cannabidiol delivery through microneedle patches

Liqun Shi, Jianfeng Xu, Lihua Zhang, Weiping Zuo, Binbin Ni, Mingqiang Lai and Maoqi Fu

Computer Methods in Biomechanics and Biomedical Engineering, 2025, vol. 28, issue 9, 1424-1436

Abstract: This study investigates the efficiency and influence of microneedle parameters, specifically Needle Point Angle (a) and Needle Height (h), on the diffusion of Cannabidiol (CBD) across varying skin depths. Utilizing the Latin Hypercube Sampling method, twelve distinct cases were analyzed. Observations reveal a consistent high concentration of CBD delivered via the microneedle patch, with a notable decrease in concentration as the depth increases, displaying a non-linear trend. Multivariate polynomial regression offers a quantitative relationship between the variables, with the third-order bivariate fitting providing the most accurate representation. Compared to other CBD delivery mechanisms, microneedle patches present enhanced CBD concentrations, circumventing challenges faced by other methods such as dosage inaccuracy, systemic absorption issues, and CBD degradation. The results highlight the potential of microneedle patches as a promising avenue for optimized transdermal drug delivery.

Date: 2025
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DOI: 10.1080/10255842.2024.2324881

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