Group sequential clinical trial designs for normally distributed outcome variables

Michael Grayling, James M. S. Wason () and Adrian Mander ()
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James M. S. Wason: MRC Biostatistics Unit

Stata Journal, 2018, vol. 18, issue 2, 416-431

Abstract: In a group sequential clinical trial, accumulated data are analyzed at numerous time points to allow early decisions about a hypothesis of interest. These designs have historically been recommended for their ethical, administrative, and economic benefits. In this article, we first discuss a collection of new commands for computing the stopping boundaries and required group size of various classi- cal group sequential designs, assuming a normally distributed outcome variable. Then, we demonstrate how the performance of several designs can be compared graphically.

Keywords: doubletriangular; haybittlepeto; innerwedge; powerfamily; triangular; wangtsiatis; clinical trial design; group sequential (search for similar items in EconPapers)
Date: 2018
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Working Paper: Group sequential clinical trial designs for normally distributed outcome variables (2017)
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