Estimation of Acute Toxicity by Fitting a Dose‐Time‐Response Surface

Kai Sun, Gary F. Krause, Foster L. Mayer, Mark R. Ellersieck and Asit P. Basu

Risk Analysis, 1995, vol. 15, issue 2, 247-252

Abstract: In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose‐response curve, and the time course of effect is usually ignored for lack of a suitable model. A model which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. The proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. The new statistical technique is also tested by a data base of a variety of chemical and fish species.

Date: 1995
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https://doi.org/10.1111/j.1539-6924.1995.tb00318.x

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Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:15:y:1995:i:2:p:247-252

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