Evaluation of False Positive and False Negative Outcomes in NTP Long‐Term Rodent Carcinogenicity Studies

J. K. Haseman and M. R. Elwell

Risk Analysis, 1996, vol. 16, issue 6, 813-820

Abstract: The decision‐making process used by the National Toxicology Program (NTP) in its evaluation of long‐term rodent carcinogenicity studies was investigated to determine whether or not this procedure resulted in an excessive number of false positive or false negative outcomes. All site‐specific tumor incidences that were found to be significantly (p 0.05) increased incidences than expected by chance, yet none were considered to be chemically‐related. However, the biological significance of interstitial cell tumor increases in F344 rats is uncertain because of the high background rate of neoplasia (>90%) for this target site.

Date: 1996
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https://doi.org/10.1111/j.1539-6924.1996.tb00832.x

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Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:16:y:1996:i:6:p:813-820

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