 An Evaluation of Risk Estimation Procedures for Mixtures of CarcinogensJing‐Shiang Hwang and James J. Chen Risk Analysis, 1999, vol. 19, issue 6, 1071-1076 Abstract: The estimation of health risks from exposure to a mixture of chemical carcinogens is generally based on the combination of information from several available single compound studies. The current practice of directly summing the upper bound risk estimates of individual carcinogenic components as an upper bound on the total risk of a mixture is known to be generally too conservative. Gaylor and Chen (1996, Risk Analysis) proposed a simple procedure to compute an upper bound on the total risk using only the upper confidence limits and central risk estimates of individual carcinogens. The Gaylor‐Chen procedure was derived based on an underlying assumption of the normality for the distributions of individual risk estimates. In this paper we evaluated the Gaylor‐Chen approach in terms of the coverage probability. The performance of the Gaylor‐Chen approach in terms the coverages of the upper confidence limits on the true risks of individual carcinogens. In general, if the coverage probabilities for the individual carcinogens are all approximately equal to the nominal level, then the Gaylor‐Chen approach shouldperform well. However, the Gaylor‐Chen approach can be conservative or anti‐conservative if some or all individual upper confidence limit estimates are conservative or anti‐conservative. Date: 1999 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:19:y:1999:i:6:p:1071-1076 Access Statistics for this article More articles in Risk Analysis from John Wiley & Sons |
Is your work missing from RePEc? Here is how to contribute.
Questions or problems? Check the EconPapers FAQ or send mail to .
EconPapers is hosted by the
School of Business at Örebro University.